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 孙凤艳 现任复旦大学教授,上海医学院,医学神经生物学国家重点实验室主任和神经生物学系系主任, 神经生物学专业长江特聘教授.
孙凤艳1976年毕业于上海医科大学医学系，1987年获上海医科大学神经药理学博士学位。1985年3月-1986年2月年任日本东京理科大学药理教研室客座研究员，1990年4月-1992年4月年任美国乔治城大学飞蒂亚神经科学研究所的国际福格蒂研究员，1992年4月-1994年9月和2000年7月-2001年2月年分别为美国乔治城大学神经科学系的访问学者和访问教授。1976年起在上海医科大学任教，1994年9月回国后被聘为该校神经生物学教授和博士研究生导师，1995年至今先后被聘为医学神经生物学国家重点实验室副主任、主任，1999年被教育部聘为神经生物学长江奖励计划特聘教授, 2001年受聘为复旦大学医学院神经生物学系的系主任。目前，她兼任中国神经科学协会常务理事、上海市神经科学协会副理事长、上海市药理科学协会的理事、《中国神经科学杂志》常务编委、《中国临床神经科学杂志》、《生理学报》及《中国药理学报》编委。她的研究分两个阶段。就读博士学位期间，在导师张安中教授的指导下，她研究发现外周血管壁上有K型阿片受体结合部位的存在，该受体兴奋时，通过抑制支配血管壁上的交感神经末梢释放去甲肾上腺素而抑制血管的收缩。1990年开始从事脑损伤及脑保护机制方面的研究。近五年来，她的研究内容为以下几个主要方面： 1.脑内神经细胞的DNA氧化损伤和修复机制; 2.神经元的再生和脑保护作用及其机制; 3.脑保护措施的基础与临床基础研究。
她先后主持和完成了国家自然科学基金委的重点、国家杰出青年基金、国家教委跨世纪人才基金、国家基础研究规划课题（973项目）以及上海市科委等重点和重大项目的研究。 她曾3次获得部委级科技进步二等奖，2003年获得上海市医学科技一等奖.曾获得全国《三八》红旗手、宝钢优秀教师、卫生部科技之星和首届明治乳业生命科学奖等荣誉称号。
SCI论文发表情况：
1. Sun Feng-Yan, Yu Gui-Hua and Zhang An-Zhong, (1983) Kappa receptor in the blood vessels, Acta Pharmacologica Sinica, 4: 100-102.
2. Li Peng, Sun Feng-Yan, and Zhang An-Zhong, (1983), The effect of acupuncture on the blood pressure: the interaction of sympathetic activity and endogenous opioid peptide, Acup & Electro-Therap Res Int J., 8: 45-56.
3. Sun Feng-Yan and Zhang An-Zhong, (1985) Inhibitory effects of dynorphin on the electrical field stimulation induced contraction of blood vessels. Acta Pharmacologica Sinica, 5: 245-248.
4. Sun Feng-Yan and Zhang An-Zhong, (1985) Dynorphin receptor in the blood vessels. Neuropeptides, 5: 595-598.
5. Kazukiku Kubota and Sun Feng-Yan , et al., (1987) Reversal of antinociceptive effect of caerulein by benzodiazepines, J. Pharmacobio-Dyn., 10: 230-233.
6. Sun Feng-Yan Zhu Han, Zhang Ling-Mei, Xu Xui-Rong and Zhang An-Zhong, (1987) Dextrophan: An antagonist for phencyclidine receptor, Life Sci., 40: 2303-2307.
7. Sun Feng-Yan Li Kuang-Yan, Zhang Ling-Mei Lu Yi-Qing and Zhang An-Zhong, (1989) Autoradiographic study for etorphine and phencyclidine receptors in the blood vessels, Acta Pharmacologica Sinica,10: 298-301.
8. Lu Yi-Feng, Sun Feng-Yan , Zhang Ling-Mei and Zhang An-Zhong, (1989) Phencyclidine receptors in pocine cerebral arteries. Acta Pharmacologica Sinica, 10: 5-8-511.
9. Lu Yi-Feng, Tong Jie-Fei, Sun Feng-Yan and Zhang An-Zhong, (1991) Effect of phencyclidine on rabbit basilar artery in vitro and rabbit cerebral blood flow in vivo, Acta Pharmacologica Sinica, 12: 461-464.
10. Bao Wei-Li and Sun Feng-Yan Zhang Li-Mei, (1991) Antagonistic effect of dextromethorphan on vasoconstriction of phencyclidine in vitro, Acta Pharmacologica Sinica, 12:242-244.
11. Bao Wei-Li and Sun Feng-Yan, Tong Jie-Fei, Zhang Lin-Mei, Zhang An-Zhong, (1991), Antagonistic effect of phencyclidine on cerebral ischemic damage of rats, Acta Pharmacologica Sinica, 12:384-351.
12. Lu Yi-Feng, Xing Ye-Zhong, Pan Bai-Shen, Li Kuan-Yan, Sun Feng-Yan and Zhang An-Zhong, (1992) Neuroprotective effects of phencyclidine on acute cerebral ischemia and reperfusion injury of rabbits, Acta Pharmacologica Sinica, 13: 218-222 .
13. Sun Feng-Yan Costa Eminio and Mocchetti Itoro (1993) Adrenal mediate the increase of hippocampal nerve growth factor biosynthesis following bicuculline convulsion, Neuropsychopharmacology, 8: 219-215.
14. Sun Feng-Yan and Faden Alan, (1994) NMDA antagonist prevents trauma-induced upregulation of protein kinase C in rat hippocampus and cerebral cortex. Brain Reseach, 661:63-69.
15. Sun Feng-Yan and Faden Alan, (1994) Low and high affinity NMDA receptor binding sites in the spinal cord: effects of traumatic injury, . Brain Reseach, 666: 88-92.
16. Sun Feng-Yan and Faden Alan, (1995) Neuroprotective effects of BW619C89, a use-dependent sodium channel bloker, in rat traumatic brain injury, Brain Reseach, 673: 133-140.
17. Sun Feng-Yan and Faden Alan, (1995) Pretreatment with antisense oligodeoxynucleotides directed against the NMDA-R1 receptor enhances survival and behaviral recovery following traumatic brain injury in rats, Brain Reseach, 693: 163-68 .
18. Li Xue-Jun, Zhang Ling-Mei, Gu Jing Zhang An-Zhong, Sun Feng-Yan, (通讯作者) (1997) Melatonin decreases production of hydroxyl radical during cerebral ischemia-reperfusion, Acta Pharmacologica Sinica, 18: 394-396.
19. Yan Yi-Ping, Ying Ke-Jie, Sun Feng-Yan, (通讯作者) (1998) Effect of glutamate transporter on neuronal damage induced by photochemical thrombotic brain ischemia, NeuroReport 9(3): 441-446
20. Yin Ke-Jie Yan Yi-Ping Sun Feng-Yan, (通讯作者) (1998) Altered expression of glutamate transporter GLAST mRNA in rat brain after photochemically induced focal ischemia, The Anatomical Record 250: 1-6
21. Yin Ke-Jie, Sun Feng-Yan, (通讯作者) (1998) Neuroprotective action of dextromethorphan in rat photochemically induced focal ischemia, Acta Phamacologica Sinica 19:223-226.
22. BAO Wei-Li, et al., Sun Feng-Yan (通讯作者) (1999): Intraventricular vascular endothelial growth factor antiboby increases infarct volume following transient cerebral ischemia Acta Phamacologica Sinica 20 (4):313-318.
23. TAO Feng, et al., Sun Feng-Yan (通讯作者) (1999): Hypoxia-ischemia altered expression of glutamate transporter EAAT1 in neonatal rat brain Acta Phamacologica Sinica 20(2):107-111.
24. LING Xiang, et al Sun Feng-Yan (通讯作者) (1999): Protective effect of melatonin on injuried cerebral neurons is associated with bcl-2 protein over-expression Acta Pharmacologica Sinica 20(5):409-414. .
25. LI Xue-Jun, PAN Bai-Shen, et al., Sun Feng-Yan (通讯作者) (1999): Effect of melatonin on production of hydroxyl radical and lactate dehydrogenase during hypoxia in rat cortical slices Acta Pharmacologica Sinica 20(3):201-205.
26. Yin Ke-Jie and Sun Feng-Yan (通讯作者) (1999) Effect of dextromethorphan, a NMDA antagonist, on DNA damage and DNA repair in rat photochemically induced cerebral ischemia, Brain Research, 815: 29-35
27. TAO Feng, Sun Feng-Yan (通讯作者) (2001) Role of excitatory amino acid transporter 1 in neonatal rat neuronal damage induced by hypoxia-ischemla. Neuroscience 102:503-51
28. Li Xue-Jun, Lu S-D, Sun Feng-Yan (通讯作者) (2002) Attenuation of melatonin in MPTP- induced dopaminergic neuronal injury associated with scavenging hydroxyl radical. Journal of Pineal Research 32; 47-53,
29. Sun Feng-Yan ,Lin X, Mao L-Z, Ge W-H, HuangY-L, Gu J. (通讯作者) (2002) Neuroprotection by melatonin against ischemic neuronal injury associated with modulation of DNA damage and repair in the rat following a transient cerebral ischemia. Journal of Pineal Research 33(1): 48-56.
30. Yang.Z.J. Sun Feng-Yan (通讯作者) (2002) Role of vascular endothelial growth factor in neuronal DNA damaged and repair in rat brain following a transient cerebral ischemia. Journal of Neuroscience Research. 70(2): 140-149
31. Xu J-Y, Zheng P, Shen D-H, Zhang L-M, Sun Feng-Yan (通讯作者) (2003) Vascular endothelial growth factor inhibits outward delayed rectifier potassium currents in acutely isolated hippocampal neuron. Neuroscience, 118(1) 59-67
32. Wei WX et al., Sun Feng-Yan et al., (2003) Interaction with general transcription factor IIF is required for the suppression of activated transcription by RPB5-mediating protein. Cell Res 13: 111-120.
33. Yang S-Z, Zhang L-M, Huang Y-L, Sun Feng-Yan (通讯作者) (2003), Distribution of Flk-1 and Flt-1 receptors in neonatal and adult rat brains. Anatomical Record 274A: 851-856
34. Cao GD., Clark RB., Pei W., Yin W., Zhang F., Sun Feng-Yan., Granhan SH., Chen J., (2003) Translocation of apoptosis-inducing factor in vulnerable neurons after transient cerebral ischemia and neuronal cultures after oxygen-glucose deprivation. J Cereb Blood Flow & Metab 23: 1137-1150
35. Qiu M-H, Zhang R, Sun Feng-Yan (通讯作者) (2003) Enhancement of ischemia-induced tyrosine phosphorylation of kv1.2 by vascular endothelial growth factor via activation of phosphotidylinosital 3’-kinase, Journal of Neurochemistry in press.
培养已毕业研究生的情况：
| 序号 |
姓 名 |
学位 |
毕业年份 |
毕 业 论 文 题 目 |
去 向 |
| 1 |
晏义平 |
博士 |
1997 |
谷氨酸载体在脑缺血及针刺抗脑缺血中的作用 |
美国 |
| 2 |
印克杰 |
博士 |
1998 |
谷氨酸能神经在缺血性神经元损伤和修复中的作用及机制 |
美国 |
| 3 |
凌 祥 |
博士 |
1999 |
褪黑素对缺血性神经元损伤的保护作用及其机制研究 |
美国 |
| 4 |
葛卫红 |
硕士 |
2000 |
大鼠脑缺血梗塞区域的（半）自动测量 |
在职硕士，美国 |
| 5 |
李学君 |
博士 |
2000 |
褪黑素的羟自由基清除作用与神经保护 |
美国 |
| 6 |
陶 锋 |
博士 |
2000 |
谷氨酸载体EAAT1在新生大鼠缺氧缺血性脑损伤中的作用 |
美国 |
| 7 |
徐建义 |
博士 |
2001 |
血管内皮生长因子对大鼠海马神经元离子通道功能的调节及其机制分析 |
加拿大 |
| 8 |
刘鹏冲 |
博士 |
2001 |
成年鼠缺血性脑损伤后神经元修复及再生的研究 |
美国 |
| 9 |
魏建设 |
博士 |
2002 |
谷氨酸转运体EAAT1在冈田酸诱导大鼠脑神经细胞退化过程中的作用研究 |
加拿大 |
| 10 |
沈迪晗 |
硕士 |
2003 |
人ERCC1 基因的克隆\表达及功能的初步研究 |
留本实验室工作 |
| 11 |
薛熠熠 |
硕士 |
2003 |
Bcl-2在脑缺血损伤中的过表达及其效应的研究 |
加拿大 |
| 12 |
邱梅红 |
博士 |
2003 |
VEGF的神经保护机制之一---- |
留本实验室工作 |
| 诱导Kv1.2 钾通道蛋白的磷酸化 |
| 13 |
杨增进 |
博士 |
2003 |
大鼠脑缺血后神经细胞自身修复机制的研究 |
美国 |
| 14 |
陈丽琴 |
博士 |
2003 |
抗凋亡蛋白Bcl-2在岗田酸诱导的神经细胞退化中的作用研究 |
北京某生物制药公司 |
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